Characterising grey-white matter relationships in recent-onset psychosis and its association with cognitive function

Abstract

Individuals with recent-onset psychosis (ROP) present widespread grey matter (GM) reductions and white matter (WM) abnormalities. While prior studies used univariate approaches, understanding how multiple GM regions relate to WM tracts is important, as psychosis involves network-level brain dysfunction. Understanding characteristic GM-WM patterns may also clarify the basis of cognitive impairments, which are potentially linked to network dysfunction in psychosis. Using multivariate analysis, we examined whole-brain GM-WM relationships and their association with cognitive abilities in ROP. We used T1 and diffusion-weighted images from 71 non-affective ROP individuals (age 22.09 ± 3.08) and 71..